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April 13, 2026

Jonathan Riess, MD, MS, and Nicholas Villanueva, MD, examine the growing role of antibody-drug conjugates (ADCs) in the treatment landscape. They discuss how ADCs offer activity across heterogeneous resistance mechanisms and may serve as a bridge when targeted options are limited. The conversation also explores how prior therapies, including earlier-line intensification, may influence ADC effectiveness and sequencing decisions.

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